In a recent study by researchers at Princesses Marget Cancer Centre, they developed genes signature biomarker that can indicate whether a patient is likely to respond to immune therapy or not. One of the researchers at the center stated that the gene signature discovered is related the body’s molecular network known as the extracellular matrix that not only supports the cells physically but also constructs them. He further added that it is important and critical to find out a way to know if some patients suffering with cancer will respond to immune therapy. The researchers have successfully found out that for cancer patients with gene signature, the extracellular matrix stands strong against the affected cells and acts as a roadblock so that the immune cells cannot break through the tumor. A senior scientist at the University Health Network said that gene signature biomarker with immunotherapy plays a significant role as the doctors are not sure and don’t know any other good way of predicting if a patient will respond to the therapy or not.
The team of scientists and researchers from various institutions used different techniques such as big data method and samples of different cancer patients. They analyzed that in some of the patients the immune cells were not passing through the tumor. This is when they thought that the extracellular matrix is possibly blocking the immune system.
Scientists develop a new Strategy to Enable Immune Therapy in Cancer Patients
In order to validate the biomarker, a senior researcher underpinned a new curative strategy which focused on how to deactivate the extracellular matrix in order to facilitate immune therapy. He added a very significant line by saying that the end objective of a medical practitioner in cancer treatment is to analyze if a patient at all needs immune therapy. For patients who are not able to respond to immunotherapy, one of the better approaches can be giving them a drug first that can help to disable extracellular matrix genes so that they patients respond to immunotherapy.