Hepatorenal syndrome or HRS is a medical condition characterized by progressive renal failure in patients with chronic liver disease or liver cirrhosis. It is a life-threatening and serious complication of cirrhosis. Patients suffering from HRS generally do not show any recognizable cause of kidney dysfunction as the kidneys themselves are not structurally damaged. It can be termed as “functional” form of kidney impairment. Patients suffering from hepatorenal syndrome generally does show a number of symptoms such as abdominal pain, fatigue, and malaise. Persons who are seriously affected also show symptoms such as yellowing of skin and whites of the eyes just similar to jaundice, an extremely enlarged liver and spleen, and accumulation of the fluid in the abdomen called as ascites.
The specific cause of hepatorenal syndrome is still unknown. Usually, it occurs in individuals with advanced liver disease, people who have dysfunction and scarring of the liver or cirrhosis. Individuals with HRS suffer from constriction of the blood vessels which provide nutrient supply to the kidneys. This results in decreased blood flow to the kidneys, leading to kidney dysfunction.
Major factor driving The Global Hepatorenal Syndrome Treatment Market is rise in incidence rate of hepatorenal syndrome. Moreover, high research and development initiatives and increased awareness among people are boost the growth of the market. Furthermore, increasing government support for development of innovative treatment products for treating orphan diseases also contribute to the growth of the global hepatorenal syndrome treatment market.
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The global hepatorenal syndrome treatment market can be classified based on type, treatment regimen, and end-user. In terms of type, the market can segmented into type 1 hepatorenal syndrome and type 2 hepatorenal syndrome. Based on treatment regimen, the global hepatorenal syndrome treatment market can be divided into medications and surgical care. The medications segment can be subdivided into vasopressin analogues, sympathomimetic agents, antioxidants, somatostatin analogs, antibiotics, and plasma volume expanders. The surgical care segment can be sub-segmented into peritoneovenous shunting, liver transplantation, surgical shunts, renal replacement therapy, and transjugular intrahepatic portosystemic shunt (TIPS). In terms of end-user, the market can be categorized into hospitals, diagnostic centers, private clinics, academic & research institutes, and others.
Major companies and research institutes engaged in the development of hepatorenal syndrome treatment products are Cumberland Pharmaceuticals, Inc., Ferring International Center S.A., Ikaria, Inc., Lahey Clinic Foundation, Inc., Orphan Therapeutics LLC, and the University of Turin.