Red blood cells in the amount of billions are produced on a daily basis in our bodies in our bone marrow, a disruption of which can result in a serious disease. Researchers from Howard medical school and Charité Universitätsmedizin in Berlin have gained an understanding as to how blood cells are formed and this can be ground-breaking for understanding the molecular foundations of blood formation process which can be used in order to treat anemia.
The researchers together have studied the molecular processes which are involved for the development and differentiation of stem cells into mature blood cells and found that when the number of organelle is reduce in the cell, it brings about A disruption in the formation of red blood cells which is commonly a trait found in patients suffering from Diamond Blackfan Anemia (DBA).
This disorder is on account of mutations which affect the organelles or ribosomes and reduces the overall protein levels. Researchers were also able to determine that the process of translation of genetic information into new proteins is affected in these ribosomes. There were evident changes at the stem cell stage of development affecting the GATA1 transcription factor which is responsible for red blood cell formation.