In a recent new study by the Karolinska Institutet, it was revealed that some specific types of proteins which play a crucial role in the neuron to neuron communication could be used in the diagnosis and treatment of dementia. The said study was published in Brain, a scientific journal.  These particular proteins could be made targets for early-stage interventions in various types of dementia suffering patients.

The Study to Focus on Synaptic Loss in Dementia Patients

Signals are passed from one neuron to another at synapse. Synapse is that very place in the nervous where such signals are passed between neurons. The recent study paper emphasizes on the synaptic dysfunction and its effect on the cognitive ability amongst the elderly people and the severity of dementia. Apart from the widely prevailing disease of Alzheimer’s, the Lewy body dementias are also considered one of the quite common types of neurodegenerative dementias that come with an acute prognosis.

The loss of Synaptic is a notable characteristic in the disease of Alzheimer’s and the same is strongly associated with the severity of dementia. Not much is known about the loss of synaptic in the dementia type of Lewy body.

This research has been the very first initiative that digs into quantitative proteome on pre-frontal and post-mortem tissues of the brain where apart from the entire comparison of proteome, the researchers also made a profile of the whole of synaptic proteome pertaining to Parkinson’s disease coupled with dementia, Alzheimer’s disease and Lewy body along with dementia patients.

The research has involved collaborators of various countries, namely Hungary, Sweden, the U.K. and Norway. The study was funded by grants from Karolinska Institutet geriatric funds, Demensfonden, Parkinsonfonden, UK Brains for Dementia Research, and Alzheimerfonden, amongst many others.

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