Pancytopenia is a medical abnormality related to the blood, wherein the number of blood components, i.e., red blood corpuscles (RBC), white blood corpuscles (WBC), and platelets decline below normal limits. The condition could be life-threatening, if not treated. The condition is characterized by fever, chills, fatigue, weakness, breathlessness, lymph nodes swelling, and splenomegaly.
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The disease is classified into two types: idiopathic and secondary. The mechanism of idiopathic type is the inapprociate activation of T-cells due to autoimmune response, which leads to rapid hemophagocytic activity. The essential blood components, such as, RBC, WBC, and platelets are engulfed and destroyed at a rapid pace through the over-phagocytosis process. Pancytopenia further leads to a disease, called hemophagocytic lymphohistiocytosis (HLH). Major causes of pancytopenia include bone marrow suppression, heavy and long-term administration of drugs, such as antibiotics (e.g. chloramphenicol, linezolid), BP regulators, chemotherapeutic agents, other viral diseases such as HIV and hepatitis, and blood cancer. Diagnostic tests include complete blood count (CBC) and immunoassay. Treatments include immunosuppressant (cytophosphamide) and bone-marrow stimulators (epoetin alfa).
In terms of region, the global pancytopenia market can be split into North America, Europe, Asia Pacific, Latin America and Middle East & Africa. North America leads the global pancytopenia market due to the presence of key players, technological advancements, and better infrastructure. The market in Asia Pacific is also expanding at a rapid pace. Key elements which drive the market in Asia Pacific include rise in global geriatric population, increase in number of blood-related disorders & infections, technological advancements in developing countries such as India, China, Japan, and government initiatives to support healthcare investments by key players in the region.
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Some of the key players operating in the global pancytopenia market include Abbott Healthcare Pvt Ltd, Life Technologies Corporation, Roche Holding AG, Beckman Coulter Inc., Bio-Rad Laboratories, Inc., and Ortho-Clinical Diagnostics.