The rapid spread of the human immunodeficiency virus (HIV) is one of the key drivers of the tuberculosis (TB) epidemic across the globe. The microorganisms hide from antibiotic inside the immune cell that should have killed the agents, thereby making the treatment time-consuming as well as difficult. In November issue of ACS Infectious Diseases, chemists from University of Connecticut stated that a new drug (antibiotics) has the ability to find and destroy the tuberculosis bacteria where they hide. Tuberculosis is one of the major causes of death from the communicable disease across the world and 25 % of overall population are suffering with tuberculosis.
Antibiotic Peptide for more Effective treatment of Tuberculosis
Mycobacterium tuberculosis bacteria held responsible for the cause. Mycobacterium enter inside the body in unique way, in this they allow themselves to be eaten mycobacterium immune cell and gradually they grow inside the immune cell. Over several month the patients suffering from the tuberculosis have to take several antibiotics to fight with the cause. As the bacteria are only predisposed to the drugs when they breakdown out of the macrophage in which they were grown and the bacteria also find new hideout to invade.
Researchers conducting the study were aiming toward developing an antibiotic that could kill the Mycobacteria hiding the safe confines of macrophages. Libardo and Angeles-Boza had also previously worked for the antibiotics which are generally originated from the fish, sea creatures as well as sea squirts. Additionally, many of the sea creatures produce antibiotics peptide (a small piece of protein like material which has special chemical quality.
Furthermore, the antibiotic peptide tested by Angeles Boza successfully damaged the mycrobacteria residing in macrophages in the lab. As they are still struggling to treat tuberculosis in mice. However, the findings of the study are limited in scope since it is difficult to test peptide drugs on mammals. The further step in the research process is to repeat the chemistry in small molecules that can be taken as a pill.