A group of researchers at the University of California have paved a way to genetically reprogram immunity cells in humans, also known as T cells, without applying viruses in order to insert DNA. The new technique is first of its kind in terms of its versatility, rapidness, and economies. This novel CRISPR genes edition technique is expected to be a boon for researchers and the medicine industry as a whole.
In the present times, the concept of cell therapies are being harnessed furiously in order to develop fresh and safe therapeutics for numerous chronic diseases pertaining to autoimmunity, cancer, and other rare disorders that are often inherited via genes from parents.
The new cut and paste molecular system offers a robust alternative to write genome sequences in human immunity cells, primarily relying on the process of electroporation, in which electrical fields are applied to the cells in order to increase their membrane permeability, although only temporarily. For over a year, the researchers experimented thousands of different variables and detected that if specific quantities of the T cells, CRISPR scissors, and DNA are collaborated and subjected to ideal electric fields, properties of T cells get enhanced.
One of the researchers claimed that their flexible and swift method will come in very handy in terms of altering, enhancing, and reprogramming T cells so that they can be given customization and hence the ability to recognize infections and destroy cancer. It must be noted that the T cells that are engineered using viruses have gained approval from the FDA in order to counter specific types of lymphoma and leukemia.